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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SHC1 All Species: 22.12
Human Site: Y427 Identified Species: 54.07
UniProt: P29353 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29353 NP_001123512.1 583 62822 Y427 E L F D D P S Y V N V Q N L D
Chimpanzee Pan troglodytes XP_513843 473 51606 L348 N G S V P R D L F D M K P F E
Rhesus Macaque Macaca mulatta XP_001112447 583 62797 Y427 E L F D D P S Y V N V Q N L D
Dog Lupus familis XP_547561 576 62206 Y420 E L F D D P S Y V N V Q N L D
Cat Felis silvestris
Mouse Mus musculus P98083 579 62589 Y423 E L F D D P S Y V N I Q N L D
Rat Rattus norvegicus Q5M824 469 51485 L344 N G S A P R D L F D M K P F E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512200 548 59956 Y378 R D Y E E H M Y V N T Q S W E
Chicken Gallus gallus XP_428819 632 69780 Y450 A R A E M P M Y V N A Q H I N
Frog Xenopus laevis Q8AY68 465 51711 R340 L R A A N G Q R D I F D M K P
Zebra Danio Brachydanio rerio XP_001921625 593 63809 Y447 G L F D D P S Y V N V D K P R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.7 99.1 94.3 N.A. 94.5 76.8 N.A. 48.8 46.8 64.6 69.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 80.9 99.4 96.2 N.A. 96.7 78.3 N.A. 62.6 62.5 69.9 76.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 93.3 0 N.A. 26.6 33.3 0 66.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 26.6 100 100 N.A. 100 26.6 N.A. 60 60 6.6 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 20 20 0 0 0 0 0 0 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 50 50 0 20 0 10 20 0 20 0 0 40 % D
% Glu: 40 0 0 20 10 0 0 0 0 0 0 0 0 0 30 % E
% Phe: 0 0 50 0 0 0 0 0 20 0 10 0 0 20 0 % F
% Gly: 10 20 0 0 0 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 10 10 0 0 10 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 20 10 10 0 % K
% Leu: 10 50 0 0 0 0 0 20 0 0 0 0 0 40 0 % L
% Met: 0 0 0 0 10 0 20 0 0 0 20 0 10 0 0 % M
% Asn: 20 0 0 0 10 0 0 0 0 70 0 0 40 0 10 % N
% Pro: 0 0 0 0 20 60 0 0 0 0 0 0 20 10 10 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 60 0 0 0 % Q
% Arg: 10 20 0 0 0 20 0 10 0 0 0 0 0 0 10 % R
% Ser: 0 0 20 0 0 0 50 0 0 0 0 0 10 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % T
% Val: 0 0 0 10 0 0 0 0 70 0 40 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % W
% Tyr: 0 0 10 0 0 0 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _